Animal virology and the interferon system; development of the interferon system during
embryonic growth; interferon inducibility as a phylogenetic marker of viruses and quasispecies populations; cloning of
avian interferons and their use as antiviral agents.

Phone:  860 486-4254
Email:  PHILIP.MARCUS@UCONN.EDU

Interferon induction and/or production and its suppression by influenza A viruses. P. I. Marcus, J. M. Rojek, and M. J. Sekellick. Journal of Virology 79:2880-2890, 2005.

Chicken interferon type I inhibits infectious bronchitis virus (IBV) replication and associated respiratory illness.  J. Pei, M. J. Sekellick, P. I. Marcus, I-S. Choi, and E. W. Collisson.  Journal of Interferon and Cytokine Research 21:1071-1077, 2001.

Immune status assessment by abundance of interferon alpha and gamma mRNA in chicken blood.  R. Novak, K. Ester, V. Savic, M.J. Sekellick, P.I. Marcus, J. W. Lowenthal, O. V.no, and W.L. Ragland.  Journal of Interferon and Cytokine Research 21:643-651, 2001.

Nomenclature of avian interferon proteins.  J.W. Lowenthal, P. Staeheli, U. Schultz, M.J. Sekellick, and P.I. Marcus.  Journal of Interferon and Cytokine Research. 21:547-549, 2001.

Combined Sequential treatment with Interferon and dsRNA abrogates virus resistance to interferon action.  P.I. Marcus and M.J. Sekellick.  Journal of Interferon and Cytokine Research. 21:423-427, 2001.

Cellular responses in chickens treated with IFN-a orally or inoculated with recombinant Marek’s disease virus expressing IFN-a.  K.W. Jarosinski, W.Jia, M.J. Sekellick, P.I. Marcus, and K.A. Schat.  Journal of Interferon and Cytonkine Research. 21:287-296, 2001.

Transient resistance of influenza virus to interferon action attributed to random multiple packaging and activity of NS genes.  M.J. Sekellick, S.A. Carra, A. Bowman, D.A. Hopkins, and P.I. Marcus. Journal of Interferon and Cytokine Research. 20:963-970, 2000.

Chicken interferon action on avian viruses. I. Oral administration of chicken interferon-a ameliorates Newcastle disease.  P.I. Marcus, L. van der Heide, and M.J. Sekellick.  Journal of Interferon and Cytokine Research. 19:881-885, 1999.

Chicken interferons type I and II enhance synergistically the antiviral state and nitric oxide secretion. M.J. Sekellick, J.W. Lowenthal, T.E. O’Neil, and P.I. Marcus, Journal of Interferon and Cytokine Research 18:407-414, 1998.

Interferons: General Features.  P.I. Marcus.  In “Encyclopedia of Virology,” 2^nd Ed., Eds. R.G. Webster and A. Granoff, Academic Press, London, England, Volume 2:733-739, 1998.

Interferon induction by viruses: XXIII.  Interferon induction as a quasispecies marker of vesicular stomatitis virus populations.  P.I. Marcus, L.L. Rodriguez, and M.J. Sekellick.  Journal of Virology 72:542-549, 1998.

Nucleic acids encoding avian interferon (IFN) proteins and recombinant methods using them.  Inventors: M.J. Sekellick, P.I. Marcus and A.F. Ferrandino, U.S. Patent # 5,641,656.  Issued June 24, 1997.

Interferon modulation of Marek’s disease virus expression.  L.M. Volpini, B.W. Calnek, B. Sneath, M.J. Sekellick, and P.I. Marcus.  Avian Diseases 40:78-87, 1996.

Stages of Marek’s disease virus latency defined by variable sensitivity to interferon modulation of viral antigen expression.  L.M. Volpini, B.W. Calnek, M.J. Sekellick, and P.I. Marcus  Veterinary Microbiology 47:99-109, 1995.