Animal Virology and the Interferon System: Including cloning, genomic organization and analysis
of induction during development of avian interferons; mechanisms of virus evasion of interferons antiviral action;
analysis of virus populations as quasispecies; use of interferon to combat poultry virus diseases.

Phone: 860 486-4635
Email: MARGARET.SEKELLICK@UCONN.EDU

 

Interferon induction and/or production and its suppression by influenza A viruses. P. I. Marcus, J. M. Rojek, and M. J. Sekellick. Journal of Virology 79:2880-2890, 2005.

Chicken interferon type I inhibits infectious bronchitis virus (IBV) replication and associated respiratory illness.  J. Pei, M.J. Sekellick, P.I. Marcus, I-S. Choi, and E.W. Collisson. Journal of Interferon and Cytokine Research 21:1071-1077, 2001.

 Immune status assessment by abundance of interferon alpha and gamma mRNA in chicken blood.  R. Novak, K. Ester, V. Savic, M.J. Sekellick, P.I. Marcus, J.W. Lowenthal, O. Vaino, and W.L. Ragland.  Journal of Interferon and Cytokine Research 21:643-651, 2001

 Nomenclature of avian interferon proteins.  J.W. Lowenthal, P. Staeheli, U. Schultz, M.J. Sekellick, and P.I. Marcus.  Journal of Interferon and Cytokine Research. 21:547-549, 2001.

 Combined sequential treatment with interferon and dsRNA abrogates virus resistance to interferon action.  P.I. Marcus and  M.J. Sekellick.  Journal of Interferon and Cytokine Research. 21:423-427, 2001.

 Cellular responses in chickens treated with IFN-a orally or inoculated with recombinant Marek’s disease virus expressing IFN-a.  K.W. Jarosinski, W. Jia, M.J. Sekellick, P.I. Marcus, and K.A. Schat.  Journal of Interferon and Cytonkine Research. 21:287-296, 2001.

 Transient resistance of influenza virus to interferon action attributed to random multiple packaging and activity of NS genes.  M.J. Sekellick, S.A. Carra, A. Bowman, D.A. Hopkins, and P.I. Marcus. Journal of Interferon and Cytokine Research. 20:963-970, 2000.

 Chicken interferon action on avian viruses. I. Oral administration of chicken interferon-a ameliorates Newcastle disease.  P.I. Marcus, L. van der Heide, and M.J. Sekellick.  Journal of Interferon and Cytokine Research. 19:881-885, 1999.

Chicken interferons type I and II enhance synergistically the antiviral state and nitric oxide secretion. M.J. Sekellick, J.W. Lowenthal, T.E. O’Neil, and P.I. Marcus, Journal of Interferon and Cytokine Research 18:407-414, 1998.

Interferon induction as a quasispecies marker of vesicular stomatitis virus populations.  P.I. Marcus, L.L. Rodriguez, and M.J. Sekellick.  Journal of Virology 72:542-549, 1998.

Nucleic acids encoding avian interferon (IFN) proteins and recombinant methods using them.  Inventors: M.J. Sekellick, P.I. Marcus and A.F. Ferrandino, U.S. Patent # 5,641,656.  Issued June 24, 1997.

Chicken Interferon gene: Cloning, expression, and analysis.  M.J. Sekellick, A.F. Ferrandino, D.A. Hopkins, and P.I. Marcus.  Journal of Interferon Research. 14: 71-79, 1994.

Development of the interferon system. I. In chicken cells development in ovo continues on time in vitro.  M.J. Sekellick, W.J. Biggers, and P.I. Marcus.  In Vitro Cellular & Developmental Biology 26:997-1003, 1990.